RiteMED Clobetasol Mechanism of Action

Pharmacology: Clobetasol propionate cream is a synthetic corticosteroid for topical dermatological use. It has anti-inflammatory, antipruritic, and vasoconstrictive properties.
Mechanism of Action: Corticosteroids diffuse across cell membranes and form complexes with specific cytoplasmic receptors. These complexes then enter the cell nucleus, bind to DNA (chromatin), and stimulate transcription of messenger RNA (mRNA) and subsequent protein synthesis of various inhibitory enzymes responsible for the anti-inflammatory effects of topical corticosteroids.
The vehicle of the formulations containing topical corticosteroids may also contribute to the therapeutic effect by providing an emollient or drying action or by increasing the transdermal absorption of the corticosteroid.
Absorption is systemic. The absorption degree of a topical pharmaceutical form may depend on the vehicle used in each formulation. Systemic side effects may occur with topical corticosteroid preparations, particularly when these preparations are used over large areas or for an extended period of time or with occlusive dressings. Rectal absorption increases when the intestinal mucosa is inflamed.
Systemic absorption of topical corticosteroids through the oral mucosa increases as the potency increases.
Metabolism of fluorinated compounds such as Clobetasol is slower in the skin therefore, they are systemically absorbed to a higher degree.